Sepsis and the B·R·A·H·M·S Procalcitonin (PCT) Assay

When seconds count, accurate results can make the difference between life and death.

 

Learn more about sepsis and share this information to help raise awareness

Sepsis is a leading cause of death in hospitals worldwide, placing a significant health and economic burden on both patients and healthcare institutions. An early and accurate diagnosis can save precious time, expense, and most importantly, lives. The Siemens Healthineers B·R·A·H·M·S Procalcitonin (PCT) Assay can aid healthcare providers in the diagnosis of sepsis.


Learn More about Sepsis

Sepsis is a life-threatening condition that arises when the body’s response to an infection injures its own tissues and organs.1 If not recognized and treated quickly with appropriate antibiotics and supportive measures, sepsis can rapidly evolve into septic shock.

  • Approximately 25% of patients with sepsis will develop septic shock, and up to 80% of patients with septic shock will die.2

What is PCT?

  • When bacterial infection is present, PCT is released from virtually every type of organ and tissue in the body.
  • Increasing serum PCT concentrations indicate increased severity of infection and a worse prognosis for the patient.

Siemens Healthineers B·R·A·H·M·S PCT Assay

There is a definite clinical need for earlier detection of sepsis. When seconds count, accurate results can make the difference between life and death.

Challenges

  • Identifying patients with sepsis early, when treatment is most likely to be effective.
  • Knowing if the antibiotics applied are appropriate and effective.
  • Predicting which patients are at the greatest risk of a poor outcome and require closer monitoring and care.
  • Reducing high costs associated with treating patients with severe sepsis and septic shock.
  • Differentiating sepsis from other inflammatory diseases, trauma, and other conditions whose clinical picture (signs, symptoms, and laboratory findings) is similar to sepsis.
  • Reducing unnecessary antibiotic use and its associated costs and side effects.

Solution: The Atellica® IM B·R·A·H·M·S PCT Assay

  • Achieve earlier sepsis diagnosis and risk assessment to help improve patient outcomes, including reduced morbidity and mortality, with high low-end sensitivity and the ability to make confident decisions in minutes.
  • Gain confidence when guiding antibiotic therapy with an assay that has optimal precision across the measurable range.
  • Deliver reliable results from a proven, trusted technology that demonstrates high agreement with the B·R·A·H·M·S PCT sensitive KRYPTOR assay.

Interpretation of results: risk assessment for progression to severe sepsis and septic shock
Data support the following interpretative risk assessment criteria on first day of ICU admission:3,4

  • PCT>2.0 ng/mL: Associated with a high risk for progression to severe sepsis and/or septic shock.
  • PCT<0.5 ng/mL: Associated with a low risk for progression to severe sepsis and/or septic shock.

Note: PCT levels < 0.5 ng/mL do not exclude an infection, because localized infections (without systemic signs) may also be associated with such low levels. If the PCT measurement is done very early after the systemic infection process has started (usually < 6 hours), these values may still be low. 

 

Percent change in PCT level over time to aid in the prediction of cumulative 28‑day mortality in patients with severe sepsis and septic shock

 

How to use PCT as an aid in antibiotic decision making

 

Consider discontinuing antibiotics when:

 


Learn About the Surviving Sepsis Campaign

The Surviving Sepsis Campaign, an initiative of the European Society of Intensive Care Medicine and the U.S. Society of Critical Care Medicine, was developed to improve the management, diagnosis, and treatment of sepsis, and to reduce the mortality rate from severe sepsis worldwide. The most recent evidence-based guidelines were published in 2016.5

Resources available from the campaign include:

  • Resuscitation and sepsis management bundles: evidence-based guidelines for the management of severe sepsis and septic shock.
  • Guidelines and instructions for implementing the campaign at medical facilities.
  • Information for healthcare professionals.
  • Information for the general public, patients, and their families.
  • Educational opportunities.

To learn more about the Surviving Sepsis Campaign please visit:
www.survivingsepsis.org

For additional resources please visit: https://www.sepsis.org/ 

References:
1. Singer M, et al. JAMA 2016;315:801-10.
2. Brun-Buisson C. Intensive Care Med 2000;26 Suppl 1:S64-74.
3. Muller B et al. Calcitonin precursors are reliable markers of sepsis in medical intensive care unit. Crit Care Med. 2000; 28(4):977–983.
4. Harbarth S, Holeckova K, Froidevaux C, et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med. 2001;164(3):396-402.
5. Rhodes A, et al. Crit Care Med 2016;45(3):486-552.


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